Women’s March Madness 2025 – Opening betting odds, lines, spread – ESPN

Mar 17, 2025, 02:00 PM ET

The 2025 women’s NCAA basketball tournament is set to tip off as 68 teams look to win it all and make their mark on history. The UCLA Bruins clinched the overall No. 1 seed after a resounding Big 10 tournament win, and spent 12 weeks at No. 1 in the AP poll.

Across the bracket is reigning champion South Carolina, who are looking to repeat history and give head coach Dawn Staley her fourth ring.

USC and Texas round out the one-seeds, and there’s a slew of dangerous teams no one wants to play. Paige Bueckers looks to lead UConn to victory in her last year as a Husky, and TCU, Notre Dame and NC State all boast impressive resumes and heaps of talent.

In the wake of stars like Caitlin Clark and Angel Reese leaving the NCAA, there’s plenty of new faces and returning veterans ready to make a deep run. JuJu Watkins and Kiki Iriafen will be aiming to win it all for the Trojans, and rookies like UConn’s Sarah Strong and Joyce Edwards of the Gamecocks are ready to show off their skills and strengths to the nation.

Here are the pregame lines, spreads and totals from each of the opening round matchups. Catch every game from the First Four to the Final Four on ABC, ESPN, ESPN2, ESPNU and ESPNEWS.

Odds are accurate as of publication time. All times eastern. For the latest odds, go to ESPN BET.

Wednesday – First Four

(11) Princeton Tigers

(11) Iowa State Cyclones -3.5

South Region 7 p.m. Purcell Pavilion, South Bend, IN

Princeton: 21-7, 12-2 in Ivy play

Iowa State: 22-11, 12-6 in Big 12 play

Moneyline: Iowa State (-170), Princeton (+145)

Total: 136.5

BPI Projection: Iowa State by 5.6, straight up: 70.2%

(16) Southern Jaguars

(16) UC San Diego Tritons -2.5

South Region 9 p.m. Pauley Pavilion, Los Angeles, CA

Southern: 20-14, 15-3 in SWAC play

UC San Diego: 20-15, 13-7 in Big West play

Moneyline: UC San Diego (-145), Southern (+125)

Total: 111.5

BPI Projection: UC San Diego by 2.6, straight up: 59.9%

Thursday – First Four

(11) Washington Huskies 1.5

(11) Columbia Lions

East Region 7 p.m. Carmichael Arena, Chapel Hill, NC

Washington: 19-13, 9-9 in Big Ten play

Columbia: 23-6, 13-1 in Ivy play

Moneyline: Washington (-115), Columbia (-115)

Total: 137.5

BPI Projection: Washington by 2.1, straight up: 58.1%

(16) William & Mary Tribe

(16) High Point Panthers

Midwest Region 9 p.m. Moody Center, Austin, TX

William & Mary: 14-18, 8-10 in CAA play

High Point: 21-11, 13-3 in Big South play

Betting lines TBD

BPI Projection: High Point by 4.3, straight up: 65.8%

Friday – Round 1

(11) Iowa State/Princeton

(6) Michigan Wolverines

South Region 11:30 a.m. Purcell Pavilion, South Bend, IN

Michigan: 22-10, 11-7 in Big Ten play

Betting lines TBD

BPI Projection: Not yet available

(13) Liberty Flames

(4) Kentucky Wildcats -16.5

Midwest Region 12 p.m. Memorial Coliseum (KY), Lexington, KY

Liberty: 26-6, 16-2 in C-USA play

Kentucky: 22-7, 11-5 in SEC play

Moneyline: Kentucky (-4000), Liberty (+1300)

Total: 138.5

BPI Projection: Kentucky by 17.9, straight up: 93.8%

(9) Indiana Hoosiers

(8) Utah Utes -2.5

East Region 1:30 p.m. Colonial Life Arena, Columbia, SC

Indiana: 19-12, 10-8 in Big Ten play

Utah: 22-8, 13-5 in Big 12 play

Moneyline: no line

Total: 140

BPI Projection: Utah by 2.1, straight up: 57.9%

(14) Stephen F. Austin Ladyjacks

(3) Notre Dame Fighting Irish -31.5

Midwest Region 2 p.m. Purcell Pavilion, South Bend, IN

Stephen F. Austin: 29-5, 16-4 in Southland play

Notre Dame: 26-5, 16-2 in ACC play

Moneyline: no line

Total: 152.5

BPI Projection: Notre Dame by 32.1, straight up: 99.3%

(12) Fairfield Stags

(5) Kansas State Wildcats -16.5

South Region 2:30 p.m. Memorial Coliseum (KY), Lexington, KY

Fairfield: 28-4, 19-1 in MAAC play

Kansas State: 26-7, 13-5 in Big 12 play

Moneyline: Kansas State (-4000), Fairfield (+1300)

Total: 135.5

BPI Projection: Kansas State by 17.5, straight up: 93.5%

(15) Fairleigh Dickinson Knights

(2) TCU Horned Frogs -30.5

Midwest Region 3:30 p.m. Schollmaier Arena, Fort Worth, TX

Fairleigh Dickinson: 28-3, 16-0 in NEC play

TCU: 31-3, 16-2 in Big 12 play

Moneyline: no line Total: 130.5

BPI Projection: TCU by 34.5, straight up: 99.5%

(13) Grand Canyon Lopes

(4) Baylor Bears -15.5

East Region 3:30 p.m. Foster Pavilion, Waco, TX

Grand Canyon: 32-2, 16-0 in WAC play

Baylor: 28-7, 15-3 in Big 12 play

Moneyline: Baylor (-2500), Grand Canyon (+1100) Total: 140.5

BPI Projection: Baylor by 19.7, straight up: 95.3%

(16) Tennessee Tech Golden Eagles

(1) South Carolina Gamecocks -42.5

Midwest Region 4 p.m. Colonial Life Arena, Columbia, SC

Tennessee Tech: 26-5, 18-2 in OVC play

South Carolina: 30-3, 15-1 in SEC play

Moneyline: no line

Total: 141.5

BPI Projection: South Carolina by 44.2, straight up: 99.9%

(13) Montana State Bobcats

(4) Ohio State Buckeyes -13.5

Midwest Region 5:30 p.m. Schottenstein Center, Columbus, OH

Montana State: 30-3, 17-1 in Big Sky play

Ohio State: 25-6, 13-5 in Big Ten play

Moneyline: Ohio State (-1600), Montana State (+800)

Total: 138.5

BPI Projection: Ohio State by 20, straight up: 95.5%

(10) Oregon Ducks

(7) Vanderbilt Commodores -5.5

West Region 5:30 p.m. Cameron Indoor Stadium, Durham, NC

Oregon: 19-11, 10-8 in Big Ten play

Vanderbilt: 22-10, 8-8 in SEC play

Moneyline: no line

Total: 75

BPI Projection: Vanderbilt by 7.1, straight up: 74.5%

(12) Ball State Cardinals

(5) Ole Miss Rebels -11.5

South Region 6 p.m. Foster Pavilion, Waco, TX

Ball State: 27-7, 16-2 in MAC play

Ole Miss: 20-10, 10-6 in SEC play

Moneyline: Ole Miss (-800), Ball State (+500)

Total: 132.5

BPI Projection: Ole Miss by 15.9, straight up: 91.9%

(10) Nebraska Cornhuskers

(7) Louisville Cardinals -3.5

West Region 6 p.m. Schollmaier Arena, Fort Worth, TX

Nebraska: 21-11, 10-8 in Big Ten play

Louisville: 21-10, 13-5 in ACC play

Moneyline: Louisville (-155), Nebraska (+135)

Total: 146.5

BPI Projection: Louisville by 1.7, straight up: 56.6%

(9) Georgia Tech Yellow Jackets

(8) Richmond Spiders -2.5

Midwest Region 7:30 p.m. Pauley Pavilion, Los Angeles, CA

Georgia Tech: 22-10, 9-9 in ACC play

Richmond: 27-6, 17-1 in A-10 play

Moneyline: Richmond (-140), Georgia Tech (+120)

Total: 138.5

BPI Projection: Georgia Tech by 5.5, straight up: 69.9%

(15) Lehigh Mountain Hawks

(2) Duke Blue Devils -30.5

West Region 8 p.m. Cameron Indoor Stadium, Durham, NC

Lehigh: 26-6, 15-3 in PAT play

Duke: 26-7, 14-4 in ACC play

Moneyline: no line

Total: 128.5

BPI Projection: Duke by 31.6, straight up: 99.2%

(12) South Florida Bulls

(5) Tennessee Lady Volunteers -19.5

South Region 8 p.m. Schottenstein Center, Columbus, OH

South Florida: 23-10, 13-4 in American play

Tennessee: 22-9, 8-8 in SEC play

Moneyline: Tennessee (-7500), South Florida (+2000)

Total: 145.5

BPI Projection: Tennessee by 18.3, straight up: 94.2%

Saturday – Round 1

(16) UC San Diego/Southern

(1) UCLA Bruins

West Region 10 p.m. Pauley Pavilion, Los Angeles, CA

UCLA: 30-2, 15-2 in Big Ten play

Betting lines TBD

BPI Projection: Not yet available

(11) Murray State Racers

(6) Iowa Hawkeyes -9.5

East Region 12 p.m. Lloyd Noble Center, Norman, OK

Murray State: 24-7, 16-4 in MVC play

Iowa: 22-10, 10-8 in Big Ten play

Moneyline: Iowa (-450), Murray State (+340)

Total: 165.5

BPI Projection: Iowa by 11.5, straight up: 85.3%

(15) Arkansas State Red Wolves

(2) UConn Huskies -44.5

East Region 1 p.m. Gampel Pavilion, Storrs, CT

Arkansas State: 21-10, 15-3 in Sun Belt play

Uconn: 31-3, 18-0 in Big East play

Moneyline: no line

Total: 145.5

BPI Projection: Uconn by 45.2, straight up: 99.9%

(12) Green Bay Phoenix

(5) Alabama Crimson Tide -12.5

South Region 1:30 p.m. XFINITY Center, College Park, MD

Green Bay: 29-5, 19-1 in Horizon play

Alabama: 23-8, 10-6 in SEC play

Moneyline: Alabama (-1200), Green Bay (+650) Total: 129.5

BPI Projection: Alabama by 16.5, straight up: 92.5%

(15) Vermont Catamounts

(2) NC State Wolfpack -20.5

West Region 2 p.m. Reynolds Coliseum, Raleigh, NC

Vermont: 21-12, 13-3 in Am. East play

NC State: 26-6, 16-2 in ACC play

Moneyline: NC State (-20000), Vermont (+3000)

Total: 123.5

BPI Projection: NC State by 26.4, straight up: 98.2%

(11) Columbia/Washington

(6) West Virginia Mountaineers

East Region 2 p.m. Carmichael Arena, Chapel Hill, NC

West Virginia: 24-7, 13-5 in Big 12 play

Betting lines TBD

BPI Projection: Not yet available

(14) Florida Gulf Coast Eagles

(3) Oklahoma Sooners -14.5

East Region 2:30 p.m. Lloyd Noble Center, Norman, OK

Florida Gulf Coast: 30-3, 18-0 in ASUN play

Oklahoma: 25-7, 11-5 in SEC play

Moneyline: Oklahoma (-1800), Florida Gulf Coast (+900)

Total: 145.5

BPI Projection: Oklahoma by 19.3, straight up: 95%

(16) UNC Greensboro Spartans

(1) USC Trojans -32.5

South Region 3 p.m. Galen Center, Los Angeles, CA

UNC Greensboro: 25-6, 13-1 in SoCon play

USC: 28-3, 16-1 in Big Ten play

Moneyline: no line

Total: 128.5

BPI Projection: USC by 38.1, straight up: 99.7%

(10) South Dakota State Jackrabbits

(7) Oklahoma State Cowgirls -5.5

West Region 3:30 p.m. Gampel Pavilion, Storrs, CT

South Dakota State: 29-3, 16-0 in Summit play

Oklahoma State: 25-6, 14-4 in Big 12 play

Moneyline: Oklahoma State (-260), South Dakota State (+200)

Total: 137.5

BPI Projection: Oklahoma State by 4.8, straight up: 67.4%

(13) Norfolk State Spartans

(4) Maryland Terrapins -15.5

West Region 4 p.m. XFINITY Center, College Park, MD

Norfolk State: 30-4, 14-0 in MEAC play

Maryland: 23-7, 13-5 in Big Ten play

Moneyline: Maryland (-3000), Norfolk State (+1200) Total: 145.5

BPI Projection: Maryland by 19.3, straight up: 95%

(14) Oregon State Beavers

(3) North Carolina Tar Heels -21.5

Midwest Region 4:30 p.m. Carmichael Arena, Chapel Hill, NC

Oregon State: 19-15, 12-8 in WCC play

North Carolina: 27-7, 13-5 in ACC play

Moneyline: North Carolina (-20000), Oregon State (+3000)

Total: 120.5

BPI Projection: North Carolina by 21.3, straight up: 96.2%

(10) Harvard Crimson

(7) Michigan State Spartans -4.5

South Region 4:30 p.m. Reynolds Coliseum, Raleigh, NC

Harvard: 24-4, 11-3 in Ivy play

Michigan State: 21-9, 11-7 in Big Ten play

Moneyline: Michigan State (-200), Harvard (+170)

Total: 136.5

BPI Projection: Michigan State by 7.5, straight up: 75.8%

(9) Mississippi State Bulldogs

(8) California Golden Bears -2.5

East Region 5:30 p.m. Galen Center, Los Angeles, CA

Mississippi State: 21-11, 7-9 in SEC play

California: 25-8, 12-6 in ACC play

Moneyline: California (-145), Mississippi State (+125)

Total: 145.5

BPI Projection: Mississippi State by 2.1, straight up: 57.8%

(9) Creighton Bluejays

(8) Illinois Fighting Illini -1.5

West Region 7:15 p.m. Moody Center, Austin, TX

Creighton: 26-6, 16-2 in Big East play

Illinois: 21-9, 11-7 in Big Ten play

Moneyline: Illinois (-120), Creighton (Even)

Total: 137.5

BPI Projection: Illinois by 1.6, straight up: 56.2%

(11) George Mason Patriots

(6) Florida State Seminoles -4.5

Midwest Region 7:45 p.m. Pete Maravich Assembly Center, Baton Rouge, LA

George Mason: 27-5, 14-4 in A-10 play

Florida State: 23-8, 13-5 in ACC play

Moneyline: Florida State (-185), George Mason (+155)

Total: 156.5

BPI Projection: Florida State by 9.9, straight up: 82%

(16) High Point/William & Mary

(1) Texas Longhorns

South Region 9:45 p.m. Moody Center, Austin, TX

Texas: 31-3, 15-1 in SEC play

Betting lines TBD

BPI Projection: Not yet available

(14) San Diego State Aztecs

(3) LSU Tigers -24.5

East Region 10:15 p.m. Pete Maravich Assembly Center, Baton Rouge, LA

San Diego State: 25-9, 11-7 in MW play

LSU: 30-5, 12-4 in SEC play

Moneyline: LSU (-50000), San Diego State (+3500)

Total: 145.5

BPI Projection: LSU by 29, straight up: 98.8%

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