The 2025 men’s NCAA Tournament is in full swing. The first round is complete and 32 programs were still in contention for the national championship at the start of second-round play.
Sunday’s action features a Round of 32 matchup between Iowa State and Mississippi in the South Region.
The Iowa State Cyclones earned a No. 3 seed in the 2025 March Madness bracket and defeated Lipscomb in the first round. The Cyclones’ opponent, the sixth-seeded Ole Miss Rebels, advanced after taking down North Carolina.
Iowa State ranks as the 10th-best team in the KenPom rankings, sporting just the 20th-best offense but 8th-ranked defense. Meanwhile, Ole Miss ranks 26th overall with the 33rd-ranked offense and 20th-ranked defense.
Here’s how our experts see Sunday’s Round of 32 clash playing out. Be sure to check out USA TODAY’s complete March Madness bracket predictions to see our team’s picks for every game. While you’re at it, don’t forget to read our tournament bold predictions and upset picks.
FOLLOW THE MADNESS: NCAA men’s tournament bracket, scores, schedules, teams and more.
Ole Miss vs. Iowa State picks and predictions
- Jordan Mendoza: Iowa State
- Paul Myerberg: Iowa State
- Erick Smith: Iowa State
- Dan Wolken: Iowa State
- Jeremy Cluff: Iowa State 72, Ole Miss 71
- Sam Hutchens: Iowa State 74, Ole Miss 68
Ole Miss vs. Iowa State date, start time, where to watch
- Game Day: Sunday, March 23
- Game Time: 7:45 p.m. ET (6:45 p.m. CT)
- Location: Fiserv Forum in Milwaukee
- TV Channel: truTV
- Live Stream: Sling TV
Watch men’s March Madness games on Sling
Iowa State vs. Ole Miss odds
Odds as of Sunday, March 23 via BetMGM.
- Spread: Iowa State (-5.5)
- Moneyline Favorite: Iowa State (-235)
- Moneyline Underdog: Ole Miss (+195)
- Total: 144.5
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