Auburn vs. Creighton odds, March Madness predictions: 2025 NCAA Tournament picks from proven simulation

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The No. 1 seed Auburn Tigers (29-5) square off against the No. 9 seed Creighton Bluejays (25-10) on Saturday in a second-round matchup in the South Region of the 2025 NCAA Tournament. The Tigers, who landed the top overall seed in the March Madness field, notched an 83-63 blowout win over Alabama State in the first round on Thursday. The Bluejays, who have advanced to at least the Sweet 16 in three of the last four NCAA Tournaments, defeated Louisville 89-75 in their first round game. Creighton is 21-13-1 and Auburn is 17-16-1 against the spread this season.

Tipoff from Rupp Arena in Lexington, Kentucky, is set for 7:10 p.m. ET. Auburn is an 8.5-point favorite in the latest Creighton vs. Auburn odds from SportsLine consensus, while the over/under for total points scored is 149.5. Before making any Auburn vs. Creighton picks, be sure to check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds. Anyone following could have seen huge returns.

Now, the model has set its sights on Auburn vs. Creighton and just locked in its March Madness predictions. You can visit SportsLine now to see the model’s picks. Here are the college basketball odds and lines for Creighton vs. Auburn:

Auburn vs. Creighton spread: Auburn -8.5
Auburn vs. Creighton over/under: 149.5 points
Auburn vs. Creighton money line: Auburn -427, Creighton +327
AUB: The Tigers are 16-18 against the spread this season.
CRE: The Blue Jays are 20-10-1 against the spread this season.
Auburn vs. Creighton picks: See picks at SportsLine

Why Auburn can cover

Auburn landed the top overall seed in the NCAA Tournament bracket and Bruce Pearl’s squad has the makings of a team that could bring home the program’s first ever national title. The Tigers are deep and balanced with five players averaging 10.6 or more points per game. Auburn cruised to an 83-63 first-round victory over Alabama State behind 23 points from Miles Kelly.

Forward Johni Broome leads the way for the Tigers. The SEC Player of the Year is averaging 18.7 points, 10.6 rebounds and 3.1 assists per game. Broome’s supporting case includes 6-foot-7 guard Chad Baker-Mazara, who averages 12.4 points, 3.1 rebounds and 2.7 assists per game. See which team to pick here.

Why Creighton can cover

Creighton was impressive in its 89-75 first-round win over Louisville. The Bluejays are one of the better shooting teams in the March Madness field, have plenty of experience playing in high profile NCAA Tournament games. Several players on head coach Doug McDermott’s roster were a part of Creighton’s last two teams that went on runs to the Elite Eight (2023) and Sweet 16 (2024).

Center Ryan Kalkbrenner will present a matchup issue for Auburn. The 7-foot-1 senior is averaging 19.2 points and 8.7 rebounds per game. Guard Steven Ashworth leads the Creighton backcourt with per game averages of 16.5 points, 6.8 assists and 4.1 rebounds per game. See which team to pick here.

How to make Creighton vs. Auburn picks

SportsLine’s model is leaning Over on the point total, projecting 153 combined points. It has also generated an against-the-spread pick that hits in well over 50% of simulations. You can only get the model’s picks at SportsLine.

So who wins Auburn vs. Creighton, and which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that has returned more than $2,000 on its college basketball picks, and find out.